منابع مشابه
Flp ribonuclease activities. Mechanistic similarities and contrasts to site-specific DNA recombination.
The ribonuclease active site harbored by the Flp site-specific recombinase can act on two neighboring phosphodiester bonds to yield mechanistically distinct chain breakage reactions. One of the RNase reactions apparently proceeds via a covalent enzyme intermediate and targets the phosphodiester position involved in DNA recombination (Flp RNase I activity). The second activity (Flp RNase II) tar...
متن کاملSerum Ribonuclease Activities and Body Weight Loss
The levels of serum ribonucleases (RNase) were determined in a control group of healthy adults and in groups of patients suffering from body weight loss secondary to Insulin Dependent Diabetes Mellitus, hyperthyroidism and hypothyroidism. The study also included a group of premature infants with body weight much less than normal. The results obtained support the correlation between the rise of ...
متن کاملProtease and ribonuclease activities in bovine pituitary lobes.
1. Acid and alkaline protease activities in bovine anterior and posterior pituitary lobes were reinvestigated by measurement of u.v. and Folin-Ciocalteu colour values of trichloroacetic acid-soluble digestion products of denatured haemoglobin. 2. Both lobes of the pituitary gland contain a cathepsin with a pH optimum at 3.8. 3. When release of u.v.-absorbing material was used as the assay there...
متن کاملStructural basis for the biological activities of bovine seminal ribonuclease.
Bovine seminal ribonuclease (BS-RNase) is a homolog of RNase A with special biological properties that include specific antitumor, aspermatogenic, and immuno-suppressive activities. Unlike RNase A, BS-RNase is a dimer cross-linked by disulfide bonds between Cys31 of one subunit and Cys32 of the other. At equilibrium, this dimer is a mixture of two distinct quaternary forms, M = M and M x M. The...
متن کاملUnraveling flp-11/flp-32 dichotomy in nematodes
FMRFamide-like peptide (FLP) signalling systems are core to nematode neuromuscular function. Novel drug discovery efforts associated with nematode FLP/FLP receptor biology are advanced through the accumulation of basic biological data that can reveal subtle complexities within the neuropeptidergic system. This study reports the characterisation of FMRFamide-like peptide encoding gene-11 (flp-11...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1998
ISSN: 0021-9258
DOI: 10.1074/jbc.273.46.30591